Short
Communication
Administration
of the antibacterial agents flumequine and oxolinic acid to small turbot (Scophthalmusmaximus
L.) by bath
O.B. Samuelsen-2003
Journal of
Applied Ichthyology, 19(1):
55
Summary:
Administration of flumequine and oxolinic
acid to turbot, Scophthalmus maximus L., by bath resulted in
significant levels of both drugs in the muscle tissue. Bath treatment using
150 mg L-1 of flumequine and 200 mg L-1 of
oxolinic acid for 72 h gave muscle concentrations of 10.2 and 6.2 µg g-1,
respectively. Excretion of both antibacterials was rapid, reaching
concentrations of 0.8 and 0.9 µg g-1, respectively, for
flumequine and oxolinic acid 24 h after the end of treatment. At day 3
post-treatment the concentration of flumequine was below the limit of
quantitation (0.1 µg g-1) of the analytical method. Based
on a minimum inhibitory concentration (MIC) of 0.0625 µg ml-1
for susceptible strains, bath treatment maintain muscle levels in excess of
0.5 µg ml-1, corresponding to eight times the MIC-value
for approximately 118 h for oxolinic acid and 104 h for flumequine.
(Department of Pharmacology, Armauer Hansens Hus,
Bergen, Norway)