Mini-Review: Biotechnological production and applications of the ω-3
polyunsaturated fatty acid docosahexaenoic acid
L. Sijtsma,
M.E. de Swaaf-2004
Applied Microbiology and Biotechnology, 64(2): 146 -
153
Abstract:
Docosahexaenoic acid (DHA) is a polyunsaturated fatty
acid composed of 22 carbon atoms and six double bonds. Because the
first double bond, as counted from the methyl terminus, is at position
three, DHA belongs to the so-called omega-3 group. In recent years, DHA has attracted much attention because of its
beneficial effect on human health. At present, fish oil is the major source
of DHA, but alternatively it may be produced by use of microorganisms.
Marine microorganisms may contain large quantities of DHA and are considered
a potential source of this important fatty acid. Some of these organisms can
be grown heterotrophically on organic substrates without light. These
processes can be well controlled and DHA with constant quality can be
produced all year round. This paper reviews recent advances in the
biotechnological production of DHA by marine microorganisms.
(Agrotechnology and Food
Innovations B.V. (previously ATO B.V.), P.O. Box 17, 6700 AA Wageningen,
The Netherlands, e-mail: lolke.sijtsma@wur.nl)